FIG. 5.

Effect of EM703 on the activation of NF-κB and AP-1. The cells were treated with EM703 before the stimulation of PMA, and the nuclear extracts were isolated for EMSA assays. The activations of both NF-κB (A) and AP-1 (B) induced by PMA were inhibited by the incubation of EM703 at a concentration of 10⁻⁵ M.