Table 2.

Genotype and phenotype comparison of TRα1 mutant mice

	TRα1-PV [21]	TRα1-R384C [23]	TRα1-L400R [22]	TRα1-P398H [19, 22]
Model	l	2	3	4
Phenotype
T3 affinity	lost	reduced	reduced	reduced
Bone development	dwarfism	growth retardation	dwarfism	normal length
TSH	elevated	normal in adulthood	normal	elevated
FT4	normal	normal in adulthood	normal	slightly elevated
T3	elevated	normal	normal	slightly elevated