Table 1. Metformin Hydrochloride microparticle and bilayered discs formulation prepared by direct compression .
| Formulations | Polymers (CP: EC) ratio | Emulsion (O 1 /O 2 ) | |||||
|
Internal organic phase
(O 1 ) |
External organic phase (O 2 ) | ||||||
|
MH
(mg) |
Ethanol
(ml) |
CP
(mg) |
EC
(mg) |
Liquid paraffin
(ml) |
Span 80
(%w/w) |
||
|
F1 F2 F3 |
1 :2 1:3 1:4 |
500 500 500 |
20 20 20 |
225 225 225 |
450 675 900 |
125 125 125 |
3 3 3 |
|
Fˊ1 Fˊ2 Fˊ3 |
1 :2 1 :3 1 :4 |
500 500 500 |
- - - |
225 225 225 |
450 675 900 |
- - - |
- - - |
* EC (Ethylcellulose), CP (Carbomer 934p) and (MH) Metformin Hydrochloride. F1, F2 and F3 microspheres formulation were compressed by single punch to 300 mg discs. Fˊ1, Fˊ2 and Fˊ3 formulation were prepared by direct compressed to bilayered disc (300 mg).