Table 3. physicochemical characteristics of gastric-mucoadhesive microparticles and bilayered discs .
| Formulation code | F 1 | F 2 | F 3 | Fˊ1 | Fˊ2 | Fˊ3 |
| Polymer (CP:EC) ratio | 1:2 | 1:3 | 1:4 | 1:2 | 1:3 | 1:4 |
| Weight variation (mg ± SD) | 298 ± 0.002 | 299 ± 0.005 | 298 ± 0.001 | 299 ± 0.001 | 298 ± 0.003 | 299 ± 0.004 |
| Hardness (N ± SD) | 24.28 ± 1.63 | 23.58 ± 2.01 | 22.29 ± 1.28 | 67.13 ± 1.03 | 61.52 ± 1.79 | 59.97 ± 1.51 |
| Friability (%±SD) | 0.30±0.03 | 5±0.63 | 15±0.85 | 0.567±0.06 | 0.708±0.08 | 0.841±0.11 |
| Content uniformity (%±SD) | 96.32 ± 0.62 | 95.95 ± 0.20 | 95.95 ± 0.20 | 96.32 ± 0.62 | 95.95 ± 0.20 | 95.45 ± 0.45 |
| pH surface (±SD) | 1.147 ± 0.01 | 1.162 ± 0.01 | 1.166 ± 0.01 | 1.288 ± 0.04 | 1.235 ± 0.04 | 1.252 ± 0.05 |
| *Swelling (%±SD) | 90.16 ± 3.55 | 83.09 ± 2.24 | 83.09 ± 2.24 | 344.12 ± 3.55 | 276.04 ± 2.24 | 221.24 ± 2.24 |
| Mucoadhesive strength (g/m 2 ±SD) | 2.74 ± 0.24 | 1.76 ± 0.27 | 0.75 ± 0.05 | 3.99 ± 0.27 | 2.99 ± 0.49 | 2.70 ± 0.29 |
| Residence time (min±SD) | 42.26 ± 0.36 | 51.51 ± 0.19 | 20.36 ± 0.35 | 97.50 ± 10.60 | 70.00 ± 14.14 | 50.00 ± 7.07 |
*All of results are related to 8th h.