Table 4. Comparison of various release characteristics of MH from different microsphere formulations, discs and commercial® tablet .
| Formulation | a Rel 2 (%) | b Rel 8 (%) | c DE | d T 50% (h) | e f 1 |
|
F1 F2 F3 |
45.02±0.74 37.25±0.90 29.5±0.78 |
75.62±0.65 73.98±1.07 68.16±1.05 |
51.78 48.21 42.32 |
4 4.4 5 |
50.22 54.34 59.15 |
|
Fˊ1 Fˊ2 Fˊ3 |
16.45±1.95 17.28±0.29 19.97±4.08 |
74.63±1.05 88.57±1.07 93.60±3.73 |
35.55 47.72 52.43 |
5.8 4.2 3.8 |
67.78 58.28 54.21 |
| Glucofage®Tab | 105.81±3.78 | 104.33±4.84 | 98.97 | >0.5 | 0 |
a Rel2 = amount of drug release after 2 h; b Rel8 = amount of drug release after 8 h; cDE = dissolution efficiency; dt 50% = dissolution time for 50% fractions; e f1 = Differential factor.