Figure 3.

Both urine volume and renal Kt/V decreased with time, but rate of change did not significantly differ between the treatment and control groups. Effects of spironolactone on residual renal function and peritoneal membrane function. (A) Changes in urine volume. Rate of change in urine volume was significantly higher in both groups after 18 months compared with baseline values but did not significantly differ between groups during the observation period. (B) Changes in residual renal function Kt/V. Changes in renal Kt/V were not significantly different compared with baseline values and did not significantly differ between groups during the observation period. (C) Peritoneal membrane function assessed by D/P Cr. Rate of change in D/P Cr did not differ between groups. 95% C.I., 95% confidence interval; Spiro (−), control group; Spiro (+), spironolactone treatment group.