Table 1.
Comparison of clinical variables between NODAT cases and controls
| Variable | NODAT (n=57) | Control (n=370) | P Value |
|---|---|---|---|
| Recipient age (yr) | 49.1±13.2 | 42.4±14.0 | 0.001 |
| Recipient sex | |||
| Male | 30 (53) | 249 (67) | |
| Female | 27 (47) | 121 (33) | 0.04 |
| Donor age (yr) | 37.1±14.8 | 37.6±16.1 | 0.80 |
| Donor sex | |||
| Male | 33 (58) | 213 (58) | |
| Female | 24 (42) | 157 (42) | 1.0 |
| Primary renal disease | |||
| GN | 7 (12) | 89 (24) | 0.07 |
| Interstitial/pyelonephritis | 15 (26) | 79 (21) | 0.50 |
| ADPKD | 16 (28) | 60 (16) | 0.05 |
| Other | 10 (18) | 84 (23) | 0.40 |
| Unknown | 9 (16) | 58 (16) | 0.70 |
| Decade of transplantation | |||
| 1986–1995 | 24 (42) | 174 (47) | |
| 1996–2005 | 33 (58) | 196 (53) | 0.60 |
| HLA mismatch (n) | 2.1±1.1 | 2.2±1.1 | 0.60 |
| Acute rejection | 9 (16) | 48 (13) | 0.90 |
| Immunosuppression | |||
| Calcineurin inhibitors | 41 (72) | 299 (81) | 0.40 |
| Azathioprine | 35 (61) | 224 (61) | 1.0 |
| Mycophenolate mofetil | 28 (49) | 185 (50) | 0.90 |
| mTOR inhibitor | 7 (12) | 34 (9) | 0.60 |
| Weight at transplant (kg) | 72.2±13.3 | 68.5±14.3 | 0.07 |
| Weight change at 1 yra | |||
| Weight loss | 9 (17) | 71 (21) | |
| Weight gain<10% | 11 (20) | 122 (36) | |
| Weight gain>10% | 34 (63) | 149 (43) | 0.04b |
Data are expressed as n (%) or mean±SD. ADPKD, autosomal dominant polycystic kidney disease; mTOR, mammalian target of rapamycin.
a
Values for weight change at 1 year were available for 396 of 427 recipients.
b
Linear by linear.