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Pyruvate preserves renal morphology in the setting of glycerol-induced AKI. Renal histology at 4 hours postglycerol injection±pyruvate treatment. (A and B) Renal cortex and outer medullary stripe, respectively, at 4 hours after glycerol+pyruvate injection showing normal histopathology. (C and D) Cortex and outer medullary stripe, respectively, at 4 hours postglycerol injection without pyruvate. Extensive brush border blebbing and tubule dilatation/early cast formation are apparent.
