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. Author manuscript; available in PMC: 2014 Apr 30.
Published in final edited form as: Cancer Res. 2013 Oct 4;73(20):6149–6163. doi: 10.1158/0008-5472.CAN-12-4617

Figure 5.

Figure 5

Mechanism of sunitinib and dasatinib on brain metastases. A and B, representative IHC of CD31 (A) and Ki67 (B) staining on the brain sections. Images were taken under ×20 objective. The brown signals are from the sections with positive staining. C, D, G, and H, quantification of the perivascular invading cells and possibility of Ki67 expression. E and F, quantification of the pixels of the vessel area and pixels of the loci-surrounding edema area. *, P < 0.05 versus vehicle; **, P < 0.01 versus vehicle.