TABLE 1.
MICs of β-lactams for S. algae KB-1, KB-2, and KB-3; S. putrefaciens CIP 8040; and E. coli DH10B
| β-Lactam(s)a | MIC (μg/ml)
|
||||
|---|---|---|---|---|---|
| S. algae KB-1, KB-2, and KB-3 | S. putrefaciens CIP 8040 |
E. colib
|
|||
| DH10B(pS-1) | DH10B(pSon)c | DH10B | |||
| Amoxicillin | 16-32 | 32 | 128 | >512 | 4 |
| Amoxicillin + CLA | 8-16 | 32 | 128 | >512 | 4 |
| Ticarcillin | 2-4 | 4 | 512 | >512 | 4 |
| Ticarcillin + CLA | 2-4 | 4 | 256 | >512 | 4 |
| Piperacillin | 1 | 1 | 4 | 32 | 2 |
| Piperacillin + TZB | 1 | 1 | 4 | 32 | 2 |
| Cephalothin | 256-512 | 64 | 4 | 4 | 4 |
| Cefuroxime | 4 | 2 | 4 | 4 | 4 |
| Cefoxitin | 16 | 4 | 1 | 4 | 4 |
| Ceftazidime | 0.25 | 0.25 | 0.12 | 0.12 | 0.06 |
| Cefotaxime | 0.12 | 0.06 | 0.06 | 0.12 | 0.06 |
| Cefepime | 0.12 | 0.06 | 0.06 | 0.06 | 0.06 |
| Cefpirome | 0.06 | 0.06 | 0.06 | 0.25 | 0.06 |
| Moxalactam | 2 | 2 | 0.12 | 2 | 0.06 |
| Aztreonam | 0.25 | 0.25 | 0.06 | 0.06 | 0.12 |
| Imipenem | 4 | 1 | 0.25 | 1 | 0.06 |
| Meropenem | 0.25 | 0.06 | 0.06 | 0.12 | 0.06 |
a
CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.
b
Recombinant plasmid pS-1 expressed β-lactamase OXA-55 from S. algae KB-1, whereas plasmid pSon expressed β-lactamase OXA-54 from S. oneidensis MR-1.
c
Data are from reference 19.