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Effect of pretreatment with BCX 2798 or BCX 2855 on virus titers from lungs of mice infected with rSV(hHN). BCX 2798 (10 mg/kg per day [▴]) and BCX 2855 (50 mg/kg per day [•]) were intranasally administered to 129x1/SvJ mice for 5 days; administration began 4 h before viral infection. Three mice per group were infected with rSV(hHN) (106.5 TCID50 per mouse). Control infected mice were treated only with PBS (▪). The averages for each group are plotted with error bars indicating the SEM.
