FIG. 1.

Time-of-addition study with benzimidazole nucleosides and control compounds. At time zero, cells in a 96-well plate were infected with HCMV. Antiviral compounds were added once to separate wells at time zero or at 8-h intervals until 88 h postinfection. Incubation was stopped at 96 h, and virus titers were determined by plaque assay. The time of compound addition is shown on the x axis, and the HCMV titer at 96 h is shown on the y axis.