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The Leloir pathway of galactose metabolism. Galactose 1-phosphate uridylyltransferase (GALT), the middle enzyme in the pathway, is profoundly impaired in patients with classic galactosemia. The three enzymes of the Leloir pathway, galactokinase (GALK), GALT, and UDP-galactose 4′-epimerase (GALE), are indicated together with the names of their encoding genes in Drosophila melanogaster.
