FIG. 2.

Impact of small molecule superoxide dismutase mimics MnTnBuOE-2-PyP⁵⁺ and MnTE-2-PyP⁵⁺ on survival of control and GALT-null Drosophila larvae exposed to galactose. Relative survival of control (open bars) and GALT-null (shaded bars) Drosophila larvae reared on foods that contained both 555 mM glucose and 200 mM galactose in the absence versus presence of the indicated levels of MnTnBuOE-2-PyP⁵⁺ (A) and MnTE-2-PyP⁵⁺ (B). Values plotted represent average±standard error of the mean. The number of cohort replicates for each experimental condition is indicated in parenthesis above the corresponding bar. Relative survival of each cohort was calculated as the ratio of the number of larvae surviving to adulthood from that cohort over the number of control (GALT+/+) larvae surviving to adulthood in the same food lacking additive. Significant differences are indicated. Corresponding data for larvae raised in the absence of galactose are presented in Supplementary Figure S1.