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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Nat Med. 2013 Nov 24;19(12):1632–1637. doi: 10.1038/nm.3393

Figure 3. ITK deficiency prevents Ctla4−/− T cell infiltration into tissues.

Figure 3

H&E sections of tissues from a. 3 weeks old Ctla4−/− and 8-12 weeks old WT, Itk−/− and DKO mice, and b. Tcrb−/− mice 4 weeks post-transfer of 107 CD4+ T cells from Ctla4−/− and DKO mice. c. (Left) H&E sections of tissues 8 weeks after PTX treatment of DKO mice. (Right) Flow cytometry profiles of ex vivo IL-2 and IL-17 production by LN CD4+ T cells from PTX-DKO mice. Data are representative of 3 independent experiments with ≥4 mice in each group.