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Toxicity of combination therapy with methotrexate/asparaginase
| Adverse event | Total events | Grade 1 | Grade 2 | Grade 3 |
|---|---|---|---|---|
| Gastrointestinal | ||||
| Nausea | 1 | 1 | ||
| Mucositis | 1 | 1 | ||
| Pancreatitis Metabolic/laboratory | 2 | 2 | ||
| AST elevation | 9 | 6 | 3 | |
| ALT elevation | 8 | 6 | 2 | |
| Hyperbilirubinemia Infection | 1 | 1 | ||
| Febrile neutropenia | 2 | 2 | ||
| Capillary leak syndrome | 1 | 1 | ||
| Tumor lysis syndrome | 3 | 3 |
Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase.
No grade 4 or grade 5 adverse events occurred in the study.
