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. 2004 May;48(5):1856–1864. doi: 10.1128/AAC.48.5.1856-1864.2004

FIG. 4.

FIG. 4.

Novobiocin binding site in the 24-kDa E. coli ParE structure. (A) Stereo view of selected amino acid side chains of the E. coli ParE novobiocin binding site. The ParE side chains shown and labeled and the corresponding E. coli GyrB residues (in parentheses) are E46 (E50), D69 (D73), R72 (R76), M74 (I78), D77 (G81), I90 (I94), R132 (R136), and T163 (T165). The E. coli GyrB novobiocin-bound ligand is colored gray. (B) Fo-Fc omit map of novobiocin contoured at the three-sigma level. Apparent in panel B are the interactions that novobiocin has with side chains E46 (3.7 Å), D77 (3.1 and 2.7 Å), M74 (3.5 Å), R72 (3.3 Å), I90 (3.8 Å), and the backbone carbonyl N42 (2.7 Å).