Table 4. Setting wise performance of the 2009 and 2011 case definitions.

		Primary (n = 314)	Secondary (n = 217)	Tertiary (n = 320)
Sensitivity	2009	75.7 (64.8–84.0)	67.7 (50.1–81.4)	81.2 (70.4–88.7)
	2011	83.7 (73.7–90.5)	87.1 (71.2–94.8)	92.7 (84.1–96.9)
Specificity	2009	42.9 (36.8–49.2)	47.9 (40.8–55.0)	38.3 (32.5–44.4)
	2011	21.7 (16.9–27.3)	27.9 (22.0–34.8)	16.7 (12.6–21.8)
PPV	2009	29.0 (23.9–34.01)	17.8 (12.7–22.9)	26.5 (21.6–31.3)
	2011	24.8 (20.0–29.6)	16.8 (11.8–21.8)	23.4 (18.8–28.0)
NPV	2009	85.1 (81.2–89.0)	89.9 (85.9–93.9)	88.1 (84.5–91.6)
	2011	81.2 (76.9–85.5)	92.9 (89.5–96.3)	89.4 (84.6–91.6)
LR+	2009	1.3 (1.1–1.5)	1.3 (1.0–1.8)	1.3 (1.1–1.5)
	2011	1.1 (0.95–1.21)	1.2 (1.0–1.4)	1.1 (1.0–1.2)
LR−	2009	0.56 (0.37–0.87)	0.67 (0.40–1.1)	0.49 (0.30–0.82)
	2011	0.75 (0.42–1.33)	0.5 (0.18–1.2)	0.4 (0.18–1.1)
DOR	2009	2.3 (1.3–4.2)	1.9 (0.86–4.3)	2.7 (1.4–5.2)
	2011	1.4 (0.7–2.9)	2.6 (0.87–7.85)	2.6 (0.98–6.8)

DOR: diagnostic odds ratio; PPV: positive predictive value; NPV: negative predictive value.