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. 2014 Apr 23;14:79. doi: 10.1186/1471-230X-14-79

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Copyright © 2014 Kuznetsov et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Biomarkers detect two subgroups of patients in the phase IIa study. Whole blood was collected at screening from 32 patients and PBMC incubated for 48 hrs in the absence or presence of Dexamethasone and/or DIMS0150. The expression levels for (A) IL-6 and (B) CD163 were analysed and the data divided into two groups using arbitrary cut-offs. In case of IL-6, one patient had an outlying IL-6 stimulation (>100 fold) and was removed from the analysis. The P-values between two groups were calculated using unpaired t-test, the P-values inside a group were calculated using paired t-test.