Table 3.
List of steroid response genes screened in biomarker assay
| Gene | Name | Gene ID | Reference | Sreening result |
|---|---|---|---|---|
| TLR9 |
Toll-like receptor 9 |
54106 |
19, 20 |
3 |
| TSP-1 |
Thrombospondin-1 |
7057 |
19 |
5 |
| TSP-2 |
Thrombospondin-2 |
7058 |
19 |
1 |
| IDO |
Indoleamine 2,3-dioxygenase 1 |
3620 |
19 |
4 |
| MARCO |
Macrophage receptor with collagenous structure |
8685 |
19 |
4 |
| IL-1β |
Interleukin 1, beta |
3553 |
19 |
1 |
| IL-1RI |
Interleukin-1 receptor type 1 |
3554 |
19 |
4 |
| IL-1RII |
Interleukin-1 receptor type 2 |
7850 |
19, 21 |
5 |
| IL-1Rα |
Interleukin-1 receptor antagonist |
3557 |
19 |
3 |
| IL-1RAP |
IL-1 receptor accessory protein |
3556 |
20 |
3 |
| IL-7Rα |
Interleukin 7 receptor, alpha |
3575 |
19 |
1 |
| IL-13Rα2 |
Interleukin-13 receptor subunit, alpha 2 |
3598 |
19 |
1 |
| CD163 |
Antigen CD163 |
9332 |
19 |
5 |
| GZMA |
Granzyme 1, serine esterase 3 |
3001 |
19 |
4 |
| GILZ |
Glucocorticoid-induced leucine zipper |
1831 |
19 |
1 |
| CD49D |
Antigen CD49D; integrin alpha 4 |
3676 |
19 |
1 |
| GRα |
Glucocorticoid nuclear receptor, isoform alpha |
2908 |
5, 20 |
3 |
| GRβ |
Glucocorticoid nuclear receptor, isoform beta |
2908 |
19, 20 |
3 |
| GRγ |
Glucocorticoid nuclear receptor, isoform gamma |
2908 |
20 |
3 |
| HSP90α |
Heat shock protein HSP 90, alpha |
3320 |
22 |
2 |
| HSP90β |
Heat shock protein HSP 90, beta |
3326 |
22 |
2 |
| UGT2 |
UDP glucuronosyltransferase 2 |
7362 |
23 |
2 |
| IRS-1 |
Insulin receptor substrate 1 |
3667 |
23 |
4 |
| FoxP3 |
Forkhead box protein P3 |
50943 |
24 |
4 |
| CFL1 |
Cofilin 1 |
1072 |
25 |
1 |
| HDAC2 |
Histone deacetylase 2 |
3066 |
26 |
1 |
| IGFBP2 |
Insulin-like growth factor binding protein 2 |
3485 |
27 |
1 |
| MDR1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
5243 |
4 |
1 |
| VitD3R |
Vitamin D (1,25- dihydroxyvitamin D3) receptor |
7421 |
17 |
1 |
| FKBP51 |
FK506 binding protein 5 |
2289 |
28 |
3 |
| GROα |
Growth-regulated gene-alpha |
2919 |
29 |
3 |
| VEGFA |
Vascular endothelial growth factor |
7422 |
30 |
2 |
| SGK |
Serum- and glucocorticoid-inducible protein kinase |
6446 |
31 |
1 |
| IFNγR1 | Interferon gamma receptor 1 | 3459 | 32 | 1 |
(1)Excluded because of too high individual variability in healthy volunteers.
(2)Excluded because Dexamethasone (Dex) response in healthy volunteers was not reliable.
(3)Excluded because difference in Dex response between steroid resistant patients and healthy volunteers was not reliable.
(4)Excluded because of missing or not reliable synergistic effect when stimulated with Dex and DIMS0150.
(5)Selected as potential biomarker because all four criteria were fulfilled (see text).