Table 5.
Area under the ROC curve (AUC) calculations for efficacy prediction of the biomarkers
| CD163 | TSP1 | IL-6 | CD163/TSP-1/IL-6 | ||
|---|---|---|---|---|---|
| Steroid response |
Dex 10-8 |
0.86 |
0.88 |
0.60 |
0.91 |
| |
Dex 10-6 |
0.85 |
0.87 |
0.83 |
0.91 |
| Steroid enhancement |
Dex 10-8 |
0.82 |
0.80 |
N/A# |
0.86* |
| |
Dex 10-6 |
0.77 |
0.81 |
N/A# |
0.96* |
| Steroid response and enhancement | Dex 10-6 | - | - | - | 0.98 |
#Not applicable as the level of repression of DIMS0150 induced expression of IL-6 is analyzed.
*Calculation was performed including steroid response data of IL-6.
Bold number indicates highest efficacy prediction.