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Schematic diagram showing the bimodal mechanism of BET proteins mediated tethering of MLV intasome to select chromatin sites. BET proteins associate with nucleosomes through interactions of BD-I and II with cognate modified H3 and H4 tails as well as motifs A and B binding directly to DNA. The ET domain in the BET proteins directly engages the C-terminal tail of MLV IN to target MLV integration near transcription start sites.
