TABLE 2.

Regimens used for prolonged administration of a high dose (30 mg/kg) of PMPA

Monkey no.	Sexa	SIV infection status	PMPA dose (mg/kg)b	Age at start of treatment with specified dose	Duration of treatment with specified dose	Age at time of euthanasia or status	Serum phosphorus level (mg/dl)c	Serum ALP level (U/liter)c	Urine glucose level (mg/dl)c	Bone lesions or other symptoms
29360	F	+	30	3 wk	4 mo	5 mo	5.2-5.4	1,245-1,279	NDd	AIDS; no gross evidence of bone lesions
29419	F	+	30	3 wk	4 mo	5 mo	2.9-4.0	1,906-2,046	ND	AIDS; no gross evidence of bone lesions
29283	F	+	30	3 wk	8 mo	9 mo	2.9-3.6	1,290-1,337	0	AIDS; radiologic evidence of bone lesions
27999	M	+	30	28 mo	11 mo		1.8	2,505	1,000-≥2,000	Severe bone weakness
			10	39 mo	1 mo	40 mo	1.3	2,762	ND	Euthanized because of severe bone lesions
28214	F	+	30	18 mo	11 mo	30 mo	1.8	3,939	ND	Severe bone lesions
29278	M	+	30	3 wk	13 mo		1.2-2.3	4,637-9,751	≥2,000	Moderate to severe bone lesions
			30 (2×/wk)	13.5 mo	8 mo	21 mo	2.1-4.0	2,684-4,176	100->2,000	AIDS
29279	M	+	30	3 wk	15 mo		1.6-3.3	1,200-1,358	250	Moderate bone lesions
			10	16 mo	6 mo	22 mo	3.8-5.8	597-1,705	0	Improvement of bone lesions; AIDS
29276	F	+	30	3 wk	15 mo		0.9-1.3	1,790-3,080	>2,000	Moderate to severe bone lesions
			10	16 mo	7 mo		1.8-4.0	1,392-4,884	500->2,000	Improvement
			5	23 mo	42 mo		1.7-4.8	575-2,388	250-1,000	Improvement
			2.5	65 mo	>25 mo	Alive at 7.5 yr	2.3-5.7	194-469	0-2,000	Stable condition
29049	M	−	30	3 days	16 mo	16 mo	1.8-7.2	815-3,181	2,000	Severe bone lesions
28006	M	+	30	22 mo	17 mo	39 mo	0.5	2,150	1,000	Moderate radiographic lesions; histological evidence of reduced bone mineralization; AIDS
29055	M	+	30	3 wk	19 mo	20 mo	1.1	815	500	Terminal simian AIDS; radiographic evidence of bone lesions
29003	M	+	30	3 wk	21 mo		1.4	5,343	≥2,000	Severe bone lesions
			No treatment	22 mo	19 mo	41 mo	3.4-6.9	878-8,894	Decreasing from ≥2,000 to 0 in 5 mo	Resolution of bone lesions; AIDS
29008	M	+	30	3 wk	25 mo		1.1-2.0	802-1,831	1,000	Moderate bone lesions
			10	26 mo	15 mo	41 mo	1.2-3.5	305-2,228	0-1,000	Some improvement, but development of AIDS
29045	M	+	30	3 wk	24 mo		1.5-2.0	1,844-2,611	250	Moderate bone lesions
			10	25 mo	42 mo		1.7-3.7	943-3,912	0-500	Improvement
			5	67 mo	7 mo		2.5-5.7	1,121-1,375	100-1,000	Improvement
			2.5	74 mo	10 mo	Alive at 7 yr	1.8-2.8	417-710	100-2,000	Improvement
29046	M	−	30	3 days	25 mo		1.7-6.7	827-1,945	250	Moderate bone lesions
			10	25 mo	53 mo		1.7-3.2	1,030-2,147	0-1,000	Improvement
			5	78 mo	>24 mo	Alive at >8 yr	2.1-3	289-647	100-250	Improvement

^aF, female; M, male.

^bAll PMPA doses were given subcutaneously once daily unless otherwise specified.

^cValues are single measurements or ranges.

^dND, not done.