TABLE 1.
In vitro synergy and indifference between caspofungin and immunosuppressants against A. fumigatus by microdilution checkerboard interactiona
| Strain | MIC (μg/ml) after 48 h of incubation
|
FIC indexb
|
|||||
|---|---|---|---|---|---|---|---|
| FK506 | CY | Caspo | Caspo + FK506 | Caspo + CY | Caspo + FK506 | Caspo + CY | |
| 119.00 | 1.56 | 3.125 | >32 (1) | 4 (0.25)/0.19 | 8 (0.25)/1.56 | 0.18 (0.37) | 0.63 (0.75) |
| 153.90 | 1.56 | 6.25 | >32 (1) | 8 (1)/0.39 | 4 (1)/1.56 | 0.38 (1.25) | 0.31 (1.25) |
| 165.86 | 6.25 | 6.25 | >32 (0.5) | 4 (0.25)/0.78 | 4 (0.5)/1.56 | 0.19 (0.63) | 0.31 (1.25) |
| AF293 | 1.56 | 3.125 | >32 (1) | 1 (0.5)/0.39 | 8 (1)/0.78 | 0.27 (0.75) | 0.38 (1.25) |
| 182.99 | 0.39 | 6.25 | >32 (1) | 4 (1)/0.097 | 16 (1)/3.125 | 0.31 (1.25) | 0.75 (1.5) |
| 168.95 | 3.125 | 6.25 | >32 (1) | 8 (0.5)/0.097 | 8 (0.5)/3.125 | 0.16 (0.53) | 0.63 (1.0) |
| 131.00 | 0.78 | 6.25 | >32 (0.5) | 4 (0.5)/0.097 | 16 (0.5)/3.125 | 0.19 (1.12) | 0.75 (1.5) |
| 101.01 | 1.56 | 25 | >32 (1) | 16 (0.5)/0.78 | 16 (1)/12.5 | 0.75 (1.0) | 0.75 (1.5) |
| Geometric mean | 1.56 | 6.25 | >32 (0.84) | 4.76 (0.5)/0.25 | 8.72 (0.65)/2.41 | 0.27 (0.80) | 0.53 (1.22) |
a
Caspo, caspofungin. Values in parentheses are MECs.
b
For FIC index calculations with caspofungin, a value of 64 was used for those isolates with an MIC of >32 μg/ml.