TABLE 2.
In vitro antagonism and indifference between voriconazole and immunosuppressants against A. fumigatus by microdilution checkerboard interaction
| Strain | MIC (μg/ml) after 48 h of incubationa
|
FIC index
|
|||||
|---|---|---|---|---|---|---|---|
| FK506 | CY | VCZ | VCZ + FK506 | VCZ + CY | VCZ + FK506 | VCZ + CY | |
| 119.00 | 0.78 | 25 | 0.25 | 0.5/0.78 | 0.5/25 | 3 | 3 |
| 153.90 | 0.78 | 25 | 0.25 | 1/1.56 | 0.5/25 | 5 | 3 |
| 165.86 | 0.78 | 12.5 | 0.5 | 1/3.125 | 1/12.5 | 6 | 3 |
| AF293 | 0.78 | 25 | 0.25 | 0.5/3.125 | 0.5/25 | 6 | 3 |
| 182.99 | 0.78 | 6.25 | 0.5 | 1/1.56 | 1/6.25 | 4 | 3 |
| 168.95 | 3.13 | 12.5 | 0.5 | 1/3.125 | 1/12.5 | 3 | 3 |
| 131.00 | 0.78 | 6.25 | 0.25 | 1/0.78 | 1/6.25 | 5 | 5 |
| 101.01 | 3.13 | 25 | 1 | 2/3.125 | 2/25 | 3 | 3 |
| Geometric mean | 1.10 | 14.87 | 0.39 | 0.92/1.86 | 0.84/14.87 | 4.20 | 3.20 |
a
VCZ, voriconazole.