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. 2014 Apr 30;9(4):e95183. doi: 10.1371/journal.pone.0095183

Figure 6. Sites under positive selection pressure in V3 region at different disease stages.

Figure 6

HIV-1 gp120 protein model is from JR-FL strain [45]. Sites under selection pressure are indicated as spheres in purple. Labeling of each positively selected site is centered on the α-carbon of the amino acid. CD4 receptor is in green. Residues involved in CCR5 binding are indicated as spheres in red. The α2 helix region is indicated in blue. Amino acid residue 300 in V3 is partially hidden by residue 441 of the C4 region, to which it is spatially close. Amino acid numbering is according to HXB2 sequence. ES  =  Early disease Stage CS  =  Chronic disease Stage LS  =  Late disease Stage.