Table 3. Amino acid sites under positive selection in gp120 V3, C3 and C4 regions of HIV-1 clade C variants from patients at different disease stages.

			Mean dN/dS ratio
Region	Position in HXB2	Position in JR-FL	ES	CS	LS
V3	300	297	3.056±0.699	3.056±0.690	4.676+1.223
	309	306	<1	3.019±0.718	4.676+1.226
	322	317	3.050±0.707	3.050±0.696	<1
C3	335	331	4.711±0.995	3.507±0.122	<1
	336	332	4.902±0.598	3.507±0.118	7.808±1.550
	337	333	4.864±0.703	3.505±0.138	<1
	343	339	4.902±0.599	3.507±0.120	<1
	344	340	4.901±0.600	3.507±0.118	<1
	346	342	4.902±0.599	3.507±0.118	<1
	347	343	<1	3.505±0.143	<1
	350	346	4.885±0.648	3.507±0.118	<1
	352	348	<1	3.494±0.220	<1
	360	355	4.902±0.598	3.504±0.145	<1
	362	357	4.902±0.598	3.507±0.118	7.807±1.552
	364	359	4.902±0.598	3.507±0.120	7.808±1.550
C4	429	420	2.935±0.911	5.321±1.659	2.905±0.591
	446	437	<1	<1	2.893±0.604

ES  =  Early disease Stage; CS  =  Chronic disease Stage; LS  =  Late disease Stage.