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. 2014 Apr 30;9(4):e95884. doi: 10.1371/journal.pone.0095884

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© 2014 Zhao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Xenograft at sacrifice. Xenografts from HCC827-pSB388 group were much larger than HCC827 group. Xenografts from HCC827-pSB388+Met group, which treated with metformin, were much smaller than that from HCC827-pSB388 group. (B) Tumor volumes were determined at the time of sacrifice. (C) Metastatic tumor nodules in the lung were examined by H & E staining of serial sections. Tumor nodules are marked with red arrows (100× and 400×). (D) The numbers of cancerous metastatic nodules in these lung sections were counted and the average number per field of view is presented. (E) E-cadherin and vimentin expression in tumor tissues from HCC827, HCC827pSB388 and HCC827pSB388+Met groups was analyzed by immunohistochemistry (400×). Error bars represent the standard deviation (*, p<0.05).