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. Author manuscript; available in PMC: 2014 Apr 30.
Published in final edited form as: Phys Med Biol. 2010 Sep 29;55(20):6141–6155. doi: 10.1088/0031-9155/55/20/007

Figure 4.

Figure 4

BBB opening using transducer-A and microbubbles as confirmed by (a) 3D sagittal MRI and (b) the corresponding spectrogram (on the signal acquired by the hydrophone) of the first pulse from 0.095 to 0.145 ms showing that the broadband acoustic emissions were detected at 0.45 MPa and 0.60 MPa but not at 0.15 MPa and 0.30 MPa. 3D MR confirmed that BBB could open at 0.30 MPa, i.e. without inertial cavitation. (c) Spectrogram of the first pulse from 0.095 to 0.145 ms in the absence of microbubbles showing that only the first and second harmonics could be detected without microbubbles.