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. Author manuscript; available in PMC: 2014 Apr 30.
Published in final edited form as: Phys Med Biol. 2010 Sep 29;55(20):6141–6155. doi: 10.1088/0031-9155/55/20/007

Figure 8.

Figure 8

2D-MR images and H&E-stained horizontal sections of the BBB-opened hippocampi at (a-c) 0.15 MPa, (d-f) 0.30 MPa, (g-i) 0.45 MPa and (j-l) 0.60 MPa using transducer-B and microbubbles. Sonicated brains at 0.15 MPa, 0.30 MPa and 0.45 MPa showed no histological damage. Minor microscopic damage was noticeable in one location of the right hippocampus sonicated at 0.60 MPa, constituting one distinct damaged site (g)-(i). Black arrows point to RBC extravasations. The black boxes inside the left and middle column show enlarged regions in the middle and right columns, respectively. Magnifications and scale bars in (a), (d), (g) and (j) are 40× and 200 μm, in (b), (e), (h) and (k) 100× and 100 μm and in (c), (f), (i) and (l) 200× and 50 μm, respectively.