Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Apr 24;7:197. doi: 10.1186/1756-3305-7-197

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Romero et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Multiple alignment of deduced amino acid sequences of CβS from T. rangeli (TrCβS) and other representative organisms. The identity (black background) and conservation (grey background) of the amino acid residues are shown. Brackets indicate the consensus amino acid residues of the putative pyridoxal phosphate-binding motif (PXXSVKDR), and other motifs vital for CβS activity are indicated with asterisks (*). The oxido-reductase motif of HsCβS is highlighted with (+). The lysine residues required for CS catalytic activity are marked with triangles. The positions of the heme-binding residues within the heme domain of the human CβS enzyme (Cys⁵² and His⁶⁵) are marked with (↓). HsCβS: Human (P35520); TcCβS: Trypanosoma cruzi (Tc00.1047053511691.20); ScCβS: Saccharomyces cerevisiae (P32582) LtaCβS: Leishmania tarentolae (LtaP17.0270); TbCβS: Trypanosoma brucei (Tb11.02.5400); LbrCβS: Leishmania braziliensis (LbrM.17.0230).