Table 2.
Functional Outcomes versus Predicted Outcomes Based on Presurgical Assessments
| Time Postsurgery |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 Months |
9 Months |
12 Months |
15 Months |
|||||||||
| Assessment Measure | Subjects with Presurgical Slope Data,a No. | Subjects with Improved Outcome, No. | Ratio | Subjects with Presurgical Slope Data,a No. | Subjects with Improved Outcome, No. | Ratio | Subjects with Presurgical Slope Data,a No. | Subjects with Improved Outcome, No. | Ratio | Subjects with Presurgical Slope Data,a No. | Subjects with Improved Outcome, No. | Ratio |
| ALSFRS | 9 | 3 | 33% | 9 | 4 | 44% | 9 | 3 | 33% | 9 | 3 | 33% |
| FVC seated | 9 | 3 | 33% | 9 | 3 | 33% | 9 | 3 | 33% | 9 | 3 | 33% |
| HHD upper | 9 | 7 | 78% | 9 | 8 | 89% | 9 | 8 | 89% | 9 | 7 | 78% |
| HHD lower | 9 | 5 | 56% | 9 | 4 | 44% | 9 | 4 | 44% | 9 | 5 | 56% |
| GST left | 8 | 7 | 88% | 8 | 8 | 100% | 8 | 7 | 88% | 8 | 7 | 88% |
| GST right | 8 | 6 | 75% | 8 | 6 | 75% | 8 | 6 | 75% | 8 | 6 | 75% |
| EIM upper | 4 | 3 | 75% | 4 | 3 | 75% | 4 | 3 | 75% | 4 | 3 | 75% |
| EIM lower | 10 | 6 | 60% | 10 | 6 | 60% | 10 | 6 | 60% | 10 | 7 | 70% |
a
Slopes were utilized to determine whether postsurgical assessment data points at 6, 9, 12, and 15 months were improved relative to predicted outcomes extrapolated from the presurgical progression rate slopes
ALSFRS = Amyotrophic Lateral Sclerosis Functional Rating Scale; EIM = electrical impedance myography; FVC = forced vital capacity; GST = grip strength assessment; HHD = hand-held dynamometry.
Ratios indicated in bold represent outcome measures that are improved in over 50% of subjects relative to points predicted from presurgical slopes.