Table 3.
Changes in clinical parameters from baseline to 12 months in both groups
| Δ, m-TOR group ( P ) | Δ, Control group ( P ) | Δ, Effect (m-TOR vs.Control), (95% CI) | P value | |
|---|---|---|---|---|
|
BMI (kg/m
2
) |
1.37 ± 7 |
0.2 ± 5 |
1.1 ± 1.3 |
0.459 |
| (0.2) |
(0.7) |
(-1.8 to 4) |
||
|
Systolic blood pressure (mmHg) |
-1.7 ± 12 |
0.98 ± 12 |
2.6 ± 2.7 |
0.324 |
| (0.6) |
(0.4) |
(-8 to 2.7) |
||
|
Diastolic blood pressure (mmHg) |
-2.8 ± 16 |
0.7 ± 14.7 |
-3.6 ± 3.5 |
0.326 |
| (0.7) |
(0.3) |
(-10 to 3.6) |
||
|
Serum creatinine (mg/dL) |
-0.44 ± 22 |
-0.55 ± 24 |
0.1 ± 5.4 |
0.985 |
| (0.7) |
(0.4) |
(-10.8 to 11) |
||
|
Hemoglobin (g/dL) |
-7.6 ± 6.6 |
-6 ± 16 |
-1.7 ± 2.6 |
0.503 |
| (0.0001) |
(0.002) |
(-6.8 to 3.4) |
||
|
Uprot (mg/24 h) |
-278 ± 572 |
-6.1 ± 98 |
-271.6 ± 116 |
0.028 |
| (0.003) |
(0.4) |
(-511 to -32) |
||
|
Cholesterol (mg/dL) |
-12.1 ± 22 |
-5.9 ± 21 |
-6.2 ± 5.2 |
0.243 |
| (0.01) |
(0.15) |
(-17 to 4.3) |
||
| Triglycerides (mg/dL) | -24.6 ± 58 |
6.3 ± 33 |
-31 ± 12.3 |
0.017 |
| (0.08) | (0.010) | (-56 to -5.8) |
Δ, percent increase or decrease from baseline ([baseline value – final value] x 100/baseline value). Data are expressed as mean ± SD. Values in parentheses are P values for the differences between final and baseline absolute values, and 95% confidence intervals for the control versus m-TOR group effect.
To convert serum creatinine in mg/dL to mol/L, multiply by 88.4; hemoglobin in g/dL to g/L, multiply by 10; cholesterol in mg/dL to mmol/L, multiply by 0.02586; triglycerides in mg/dL to mmol/L, multiply by 0.01129.
Abbreviations: BMI, body mass index; Uprot, daily urinary protein excretion.