Table 4.
Changes in echocardiographic parameters from baseline to 12 months in both groups
| Δ, m-TOR group ( P ) | Δ, Control group ( P ) | Δ Effect (m-TOR vs Control) (95%CI) | P value | |
|---|---|---|---|---|
|
LAD (mm) |
0.90 ± 15 |
0.30 ± 14 |
0.59 ± 3.4 |
0.859 |
| (0.4) |
(0.6) |
(-6 to 7.3) |
||
|
LVEDD (mm) |
45.8 ± 10 |
44 ± 9 |
1.8 ± 2.1 |
0.428 |
| (0.7) |
(0.2) |
(-2.5 to 5.8) |
||
|
IVS (mm) |
5.3 ± 8.5 |
3.1 ± 16 |
2.2 ± 2.7 |
0.427 |
| (0.002) |
(0.04) |
(-3.1 to 7.4) |
||
|
PWT (mm) |
7 ± 10 |
4.9 ± 14 |
2.1 ± 2.7 |
0.415 |
| (0.001) |
(0.01) |
(-3.1 to 7.5) |
||
|
RWT |
4.8 ± 14 |
5 ± 17 |
0.2 ± 3.7 |
0.949 |
| (0.026) |
(0.035) |
(-7.1 to 7.6) |
||
|
EF (%) |
6.6 ± 11 |
0.5 ± 16 |
6.1 ± 3.6 |
0.101 |
| (0.7) |
(0.2) |
(-1.2 to 13) |
||
|
FS (%) |
-1.05 ± 21 |
-8 ± 25 |
7.1 ± 5.4 |
0.197 |
| (0.2) |
(0.02) |
(-3.7 to 18) |
||
|
LVMi (g/m
2.7
) |
8.4 ± 18 |
3.8 ± 16 |
4.5 ± 3.9 |
0.255 |
| (0.003) |
(0.052) |
(-3.4 to 12) |
||
|
Peak E (cm/sec) |
-19.4 ± 43 |
-6.4 ± 25.6 |
-13 ± 9 |
0.135 |
| (0.034) |
(0.4) |
(-30 to 4.6) |
||
|
Peak A (cm/sec) |
-11.1 ± 33 |
-9.3 ± 27 |
-1.7 ± 7 |
0.808 |
| (0.3) |
(0.1) |
(-16 to 12) |
||
|
E/A ratio |
-0.06 ± 0.34 |
-0.001 ± 0.34 |
-12.6 ± 9.8 |
0.429 |
| (0.3) |
(0.9) |
(-32 to 7) |
||
|
DT (msec) |
-18.2 ± 9 |
-5 ± 40 |
-13 ± 7.8 |
0.019 |
| (0.05) |
(0.8) |
(-29 to 3.5) |
||
| LVIRT (msec) | -10.3 ± 33 |
-3 ± 31 |
-7.1 ± 7.5 |
0.341 |
| (0.4) | (0.5) | (-22 to 8) |
Δ, percent increase or decrease from baseline ([baseline value – final value] x 100/baseline value). Values are expressed as mean ± SD; values in parentheses are P values for the differences between final and baseline absolute values, and 95% confidence intervals for the control versus m-TOR group effect.
Abbreviations: LAD, left atrial diameter; LVEDD, left ventricular end-diastolic diameter; IVS, interventricular septal thickness; PWT, posterior wall thickness; RWT, relative wall thickness; FS, left ventricular fractional shortening; LVMI, left ventricular mass index; Peak E, peak early diastolic flow velocity; peak A, peak late diastolic flow velocity; E/A ratio, ratio of early to late diastolic flow; DT deceleration time of E wave; LVIRT, left ventricular isovolumetric relaxation time.