Table 2.
Neutralization activity of stapled peptide 1 in single-cycle assay against a panel of HIV-1 ENV pseudotyped reference viruses
| NIH # | ENV clone | Subtype | IC50 (μM) |
|---|---|---|---|
| 11889 | QB726.70M.ENV.B3 | A | ~15.4 |
| 11891 | QF495.23M.ENV.A3 | A | 1.4 ± 0.06 |
| 11892 | QF495.23M.ENV.B2 | A | ~10 |
| 11896 | QH343.21M.ENV.A10 | A | ~15.4 |
| 11901 | QA790.204I.ENV.A4 | AD | 7.0 ± 0.3 |
| 11904 | QA790.204I.ENV.E2 | AD | ~7.7 |
| 11601 | CRF02_AG (Clone 263) | AG | 4.4 ± 0.25 |
| 11591 | CRF02_AG (Clone 211) | AG | 4.0 ± 0.7 |
| 11035 | pREJO4541 clone 67 (SVPB16) | B | 3.4 ± 0.5 |
| 11036 | pRHPA4259 clone 7 (SVPB14) | B | 1.6 ± 0.3 |
| 11038 | pCAAN5342 clone A2 (SVPB19) | B | 4.6 ± 0.5 |
| 11022 | PVO, clone 4 (SVPB11) | B | 3.5 ± 0.1 |
| 11058 | SC422661, clone B (SVPB8) | B | 3.7 ± 0.6 |
| 11306 | Du156, clone 12 (SVPC3) | C | 17.9 ± 1.7 |
| 11311 | ZM233M.PB6, SVPC9 | C | 3.6 ± 0.5 |
| 11315 | ZM135M.PL10a, SVPC15 | C | 1.0 ± 0.2 |
| 11507 | HIV-25925-2, clone 22 | C | 1.1 ± 0.2 |
| 11508 | HIV-26191-2, clone 48 | C | 6.3 ± 0.1 |
| 11912 | QA013.70I.ENV.M12 | D | ~15.4 |
| 11913 | QA465.59M.ENV.A1 | D | ~15.4 |
| 11914 | QA465.59M.ENV.D1 | D | ~7.7 |
| 11916 | QD435.100M.ENV.B5 | D | ~15.4 |
| 11917 | QD435.100M.ENV.A4 | D | 1.0 ± 0.3 |
| 11918 | QD435.100M.ENV.E1 | D | ~15.4 |