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. 2014 Apr 27;9:61. doi: 10.1186/1750-1172-9-61

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Copyright © 2014 Wixner et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Impact of gastrointestinal symptoms on HRQoL in patients with TTR mutations. For each gastrointestinal symptom, patients with a given symptom were compared with those without the symptom. In the V30M group, each symptom had a significant negative impact on health-related quality of life (HRQoL), whereas in the non-V30M group, all symptoms except for alternating diarrhea/constipation showed a significant negative impact. The EQ-5D Index Score was used to assess the HRQoL and full health is represented by a score of 1. The TTR V122I, I68L and L111M mutations were excluded from the non-V30M group; p < 0.05 was regarded as statistically significant. Data are presented as box and whisker plots showing median (horizontal line), interquartile range (box), mean (circle) and range of measurements (whisker).