Table 2.
Distribution of GI symptoms in patients with ATTR amyloidosis
| Symptom |
Wild-type |
TTR mutation |
|---|---|---|
| n = 140 | n = 1114 | |
| Any GI symptom |
21 (15.3%) |
696 (63.0%) |
| Early satiety |
5 (3.6%) |
291 (26.4%) |
| Nausea |
3 (2.2%) |
189 (17.1%) |
| Vomiting |
0 (0.0%) |
147 (13.4%) |
| Constipation |
5 (3.6%) |
230 (20.9%) |
| Diarrhea/constipation |
2 (1.5%) |
267 (24.3%) |
| Diarrhea |
5 (3.6%) |
218 (19.8%) |
| Fecal incontinence |
0 (0.0%) |
68 (6.2%) |
| Unintentional weight loss | 4 (2.9%) | 346 (31.5%) |
Number of patients, n (%), reporting gastrointestinal (GI) symptoms at enrollment.