Table 4.
GI symptoms in relation to age at onset in patients with TTR mutations
| Symptom |
<50 years |
≥50 years |
p value |
|---|---|---|---|
| n = 725 | n = 381 | ||
| Any GI symptom |
509 (70.3%) |
185 (49.6%) |
<0.001 |
| Early satiety |
243 (33.7%) |
48 (12.9%) |
<0.001 |
| Nausea |
157 (21.7%) |
32 (8.6%) |
<0.001 |
| Vomiting |
130 (18.0%) |
17 (4.6%) |
<0.001 |
| Constipation |
154 (21.3%) |
75 (20.2%) |
0.685 |
| Diarrhea/constipation |
201 (27.8%) |
66 (17.8%) |
<0.001 |
| Diarrhea |
164 (22.7%) |
53 (14.4%) |
0.001 |
| Fecal incontinence |
51 (7.0%) |
17 (4.6%) |
0.112 |
| Unintentional weight loss | 270 (37.4%) | 76 (20.6%) | <0.001 |
Number of patients, n (%), reporting gastrointestinal (GI) symptoms at enrollment.