Table 6.
Multiple regression analysis on factors associated with HRQoL in patients with TTR mutations
| Predictor variable | Parameter estimate | Standard error | t value | p value |
|---|---|---|---|---|
| Intercept |
0.99 |
0.03 |
30.53 |
<0.001 |
| Gender (male vs. female) |
0.00 |
0.01 |
-0.11 |
0.909 |
| Age at onset (early vs. late) |
-0.09 |
0.01 |
-6.19 |
<0.001 |
| Disease duration (years) |
-0.01 |
0.00 |
-6.90 |
<0.001 |
| Upper GI symptoms |
-0.07 |
0.01 |
-4.77 |
<0.001 |
| Lower GI symptoms |
-0.13 |
0.01 |
-9.28 |
<0.001 |
| LTx at enrollment | 0.06 | 0.02 | 3.19 | 0.002 |
Health-related quality of life (HRQoL) was assessed with the EQ-5D Index Score. Age of onset <50 years was regarded as early-onset. GI: gastrointestinal; LTx: liver transplant.