Table 4.
Standardised incidence ratios of second primary cancers at >60 days - 5 years
| |
Registry |
IARC/IACR rules |
SEER rules |
Registry‡ |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First primary cancer | Number with second cancer | SIR (95% CI) | Number with second cancer | SIR (95% CI) | Number with second cancer | SIR (95% CI) | Number with second cancer | SIR‡ (95% CI) | ||||
| Lung (C33-34) |
119 |
0.79 |
(0.65, 0.94) |
105 |
0.69 |
(0.57, 0.84) |
112 |
0.74 |
(0.61, 0.89) |
98 |
0.83 |
(0.67, 1.01) |
| Colorectal (C18-20) |
324 |
0.89 |
(0.80, 1.00) |
301 |
0.83 |
(0.74, 0.93) |
323 |
0.89 |
(0.80, 1.00) |
271 |
0.86 |
(0.76, 0.97) |
| Female breast (C50) |
363 |
0.96 |
(0.86, 1.06) |
272 |
0.71 |
(0.63, 0.80) |
348 |
0.92 |
(0.82, 1.02) |
274 |
0.96 |
(0.85, 1.08) |
| Age <50 |
52 |
2.13 |
(1.58, 2.78) |
25 |
1.02 |
(0.65, 1.50) |
49 |
2.00 |
(1.48, 2.64) |
28 |
1.67 |
(1.11, 2.42) |
| Age ≥50 |
311 |
0.88 |
(0.78, 0.98) |
247 |
0.69 |
(0.61, 0.78) |
299 |
0.84 |
(0.75, 0.94) |
246 |
0.92 |
(0.81, 1.04) |
| Prostate (C61) |
342 |
0.71 |
(0.63, 0.79) |
339 |
0.70 |
(0.63, 0.78) |
323 |
0.89 |
(0.80, 1.00) |
339 |
0.88 |
(0.79, 0.98) |
| Head & neck (C00-C14, C30-C32) |
204 |
1.93 |
(1.67, 2.21) |
196 |
1.85 |
(1.60, 2.13) |
201 |
1.90 |
(1.64, 2.18) |
176 |
1.74 |
(1.49, 2.02) |
| Stomach (C16) |
46 |
1.05 |
(0.77, 1.40) |
43 |
0.98 |
(0.71, 1.32) |
44 |
1.00 |
(0.73, 1.35) |
43 |
1.02 |
(0.74, 1.38) |
| Bladder (C67) |
140 |
1.41 |
(1.19, 1.67) |
138 |
1.39 |
(1.10, 1.55) |
140 |
1.41 |
(1.19, 1.67) |
139 |
1.46 |
(1.23, 1.73) |
| Oesophagus (C15) |
26 |
0.80 |
(0.52, 1.17) |
25 |
0.77 |
(0.50, 1.13) |
25 |
0.77 |
(0.50, 1.13) |
25 |
0.80 |
(0.51, 1.18) |
| Melanoma (C43) |
102 |
1.35 |
(1.10, 1.64) |
75 |
0.98 |
(0.77, 1.23) |
102 |
1.35 |
(1.10, 1.64) |
75 |
1.01 |
(0.79, 1.27) |
| Ovarian (C56) |
19 |
0.61 |
(0.36, 0.95) |
18 |
0.58 |
(0.34, 0.91) |
19 |
0.61 |
(0.37, 0.95) |
18 |
0.60 |
(0.36, 0.95) |
| All of above | 1685 | 0.96 | (0.91, 1.00) | 1512 | 0.86 | (0.81, 0.90) | 1637 | 1.00 | (0.95, 1.05) | 1458 | 0.99 | (0.94, 1.04) |
‡excluding same site.
Abbreviations:SEER Surveillance Epidemiology and End Results, IARC International Agency for Research on Cancer, IACR International Association of Cancer Registries, SIR standardised incidence ratio, CI confidence interval.