Figure 2.

Transcriptional profiling identifies key differences that distinguish IPF from control mesenchymal progenitor cells. A: Histogram of gene-by-gene P values that compare IPF and control mesenchymal progenitor cells. Data shown are from eight independent mesenchymal progenitor cell lines. B: Validation testing for FLT1, MAP3K8, IGF2BP1, and YBX1. Shown are relative expression levels of each mRNA by qPCR. Data shown represent the average of two cell lines. C: Heatmap of the 50 most significantly altered genes that distinguish IPF from control mesenchymal progenitor cells. Colors represent per gene z-score (expression difference normalized for SD). n = 4 (IPF and control).