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Summary of UVB-Induced Skin Carcinogenesis in Ptch+/− Haired and Hairless Littermates
| Parameters | Haired | Hairless |
|---|---|---|
| Tumor latency (weeks) | 32 | 22 |
| Cumulative UVB dose required to develop first tumor (J) | 23.04 | 7.92 |
| Tumor incidence (%) | 40 (at week 44) | 100 (at week 32) |
| Average no. of tumors per mouse | 2.5 | 12.5 |
| Tumor spectrum | Papilloma, SCC, BCC, and spindle-cell tumors | Papilloma, SCC, BCC, trichoblastoma, and rhabdomyosarcomas |
| Male/female distribution of tumors | 4.5:1 | 1.43:1 |
