Figure 6.
X-ray crystallographic structures of other notable agonists. (A) L. stagnalis AChBP in complex with nicotine (PDB entry 1UW6). (B) L. stagnalis AChBP in complex with imidacloprid (PDB entry 2ZJU). A red sphere illustrates the oxygen atom of a water molecule that bridges agonist pyridines to backbone Leu102 carbonyl and Met114 amide groups. In each illustration, numerous segments have been removed for clarity, including Loop C, of which only selected side chains are visible.