Figure 5.
Western Blotting of NF-κB, MMP-2, and Akt in WT, and EphA2-R-M Hearts. NF-κB expression (A) was elevated nearly 3-fold in WT hearts 4 days post-MI compared with baseline (*p < 0.01). A similar increase was not observed in EphA2-R-M hearts compared with baseline. Both MMP-2 proenzyme and active form were 6- and 3-fold higher in WT hearts post-MI (B) respectively (*p < 0.05). No change in MMP-2 expression was observed in EphA2-R-M hearts. The expression of Akt and p-Akt was significantly decreased in EphA2-R-M hearts post-MI and it was unchanged in WT hearts (*p < 0.05) (C).