Fig. 1.

Optical properties from diffuse optical spectroscopy (DOS) of all 14 animals at the baseline. (a) Baseline broadband scattering coefficients of frequency domain measurement ($\text{mean}\pm \text{standard deviation}$) and power-law fit estimated broadband reduced scattering coefficient at baseline (mean, blue line), (b) absolute broadband absorption spectra ($\text{mean}\pm \text{standard deviation}$) at baseline are shown. Black circles (in every 5 nm), blue line, and red dots represent measured absorption coefficients, DOS fitted absorption coefficients and residuals (measured—DOS fitted absorption coefficient), respectively. (c) Estimated differential pathlength factor (DPF) of all 14 animals at the baseline ($\text{mean}\pm \text{standard deviation}$) of five discrete wavelengths used for frequency domain measurements of DOS. DPFs are estimated using the baseline absorption and reduced scattering coefficients and the equation described by Fantini et al. (Ref. 46). The distance between source and detector is 10 mm. (d) Time profile of the estimated DPF of five discrete wavelengths used in DOS measurement. Data are from a single animal in the 10 mg cyanide (CN) group. The distance between the source and detector is 10 mm and the equation described by Fantini et al. is used for the estimation.