Fig. 3.

Changes in hemoglobin concentration and CcO redox state during saline infusion (60 cc) and inspired oxygen concentration challenges in the control animal group ($n=5$). During saline infusion, no significant change occurs in OxyHb, DeOxyHb, or CcO redox state until the inspired oxygen concentration is decreased briefly from 100% to 21% (${\mathrm{F}}_{\mathrm{I}}{\mathrm{O}}_2$ challenges indicated by red arrows). During the ${\mathrm{F}}_{\mathrm{I}}{\mathrm{O}}_2$ challenges, $\mathrm{\Delta }\mathrm{CcO}$ changes in parallel with changes in OxyHb concentration.