Fig. 4.

Changes in hemoglobin concentrations and CcO redox state during CN poisoning and inspired oxygen concentration challenges in 10 mg CN group ($n=5$). Ten milligrams of sodium CN is infused continuously at a rate of $1\mathrm{cc}/\min$. Animals receive progressively increasing amount of CN ($0.167\mathrm{mg}\mathrm{NaCN}/\min$) for 60 min. (a and b) Changes in OxyHb and DeOxyHb concentrations and $\mathrm{\Delta }\mathrm{CcO}$ changes, respectively. Error bars represent standard error of mean (SEM). During CN infusion, OxyHb changes trend opposite direction of $\mathrm{\Delta }\mathrm{CcO}$ change. However, during ${\mathrm{F}}_{\mathrm{I}}{\mathrm{O}}_2$ challenges the transient drops in OxyHb are accompanied by similar directional changes in $\mathrm{\Delta }\mathrm{CcO}$.