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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Lab Invest. 2014 Mar 10;94(5):545–556. doi: 10.1038/labinvest.2014.43

Figure 2. Smad3 deficiency suppresses the accumulation of bone marrow-derived fibroblasts in the kidney in response to obstructive injury.

Figure 2

A. Representative photomicrographs of kidney sections from WT and Smad3-KO mice 1 week after UUO stained for CD45 (red), procollagen I (green), and DAPI (blue). B. Quantitative analysis of CD45+ and procollagen I+ fibroblasts in the kidney of WT and Smad3-KO mice 1 week after UUO. ** P < 0.01 vs WT controls, + P < 0.05 vs KO UUO, and # P < 0.05 vs WT UUO. n=4 per group. C. Representative cytometric diagrams showing the effect of Smad3 deficiency on the accumulation of CD45 and DDR2 dual positive fibroblasts in the kidney in response to UUO. D. Quantitative analysis of CD45 and DDR2 dual positive fibroblasts in the kidney in response to UUO. ** P < 0.01 vs WT control, + P < 0.05 vs KO UUO, and # P < 0.05 vs WT UUO. n=3–4 per group.