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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Lab Invest. 2014 Mar 10;94(5):545–556. doi: 10.1038/labinvest.2014.43

Figure 6. Smad3 deficiency in bone marrow-derived cells inhibits myeloid fibroblast accumulation and fibrosis.

Figure 6

A. Representative photomicrographs of kidney sections from WT mice transplanted with Smad3+/+ bone marrow cells and WT mice transplanted with Smad3−/− bone marrow cells 1 week after UUO stained for CD45 (red), procollagen I (green), and DAPI (blue). B. Quantitative analysis of CD45+ and procollagen I+ fibroblasts in the kidney. ** P < 0.01 vs WT→WT controls, + P < 0.05 vs KO→WT UUO, and # P < 0.05 vs WT→WT UUO. n=5 per group. C. Representative photomicrographs show kidney sections stained with picrosirius red for assessment of total collagen deposition. D. Quantitative analysis of renal interstitial collagen content in different groups as indicated. ** P < 0.01 vs WT→WT controls, + P < 0.05 vs KO→WT UUO, and # P < 0.05 vs WT→WT UUO. n=5 per group.