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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Lab Invest. 2014 Mar 10;94(5):545–556. doi: 10.1038/labinvest.2014.43

Figure 8. Schematic illustration of the signaling events leading to activation of myeloid fibroblasts.

Figure 8

TGF-β1 binding to its receptor results in Smad3 phosphorylation. The phosphorylated Smad3 along with Smad4 is translocated into the nucleus, where it induces expression of ECM genes and activation of myeloid fibroblasts.